High frequency of MYC gene amplification is a common feature of radiation‐induced sarcomas. Further results from EORTC STBSG TL 01/01
Identifieur interne : 000189 ( France/Analysis ); précédent : 000188; suivant : 000190High frequency of MYC gene amplification is a common feature of radiation‐induced sarcomas. Further results from EORTC STBSG TL 01/01
Auteurs : Christoph K Cker [Allemagne] ; Alexander Marx [Allemagne] ; Katharina Mössinger [Allemagne] ; Frederike Svehla [Allemagne] ; Ulrike Schneider [Allemagne] ; Pancras Cornelis Wilhelmus Hogendoorn [Pays-Bas, Allemagne] ; Ole Steen Nielsen [Danemark, Allemagne] ; Stefan Küffer [Allemagne] ; Christian Sauer [Allemagne] ; Cyril Fisher [Royaume-Uni, Allemagne] ; Christian Hallermann [Allemagne] ; Jörg Thomas Hartmann [Allemagne] ; Jean-Yves Blay [France, Allemagne] ; Gunhild Mechtersheimer [Allemagne] ; Peter Hohenberger [Allemagne] ; Philipp Ströbel [Allemagne]Source :
- Genes, Chromosomes and Cancer [ 1045-2257 ] ; 2013-01.
Abstract
Irradiation is a major causative factor among the small subgroup of sarcomas with a known etiology. The prognosis of radiation‐induced sarcomas (RIS) is significantly worse than that of their spontaneous counterparts. The most frequent histological subtypes include undifferentiated pleomorphic sarcomas, angiosarcomas, and leiomyosarcomas. A high frequency of MYC amplifications in radiation‐induced angiosarcomas, but not in primary angiosarcomas, has recently been described. To investigate whether MYC amplifications are also frequent in RIS other than angiosarcomas, we analyzed the MYC amplification status of 83 RIS and 192 sporadic sarcomas by fluorescence in situ hybridization. We found significantly higher numbers of MYC amplifications in RIS than in sporadic sarcomas (P < 0.0001), especially in angiosarcomas, undifferentiated pleomorphic sarcomas, and leiomyosarcomas. Angiosarcomas were special in that MYC amplifications were particularly frequent and always high level, while other RIS showed low‐level amplifications. We conclude that MYC amplifications are a frequent feature of RIS as a group and may contribute to the biology of these tumors. © 2012 Wiley Periodicals, Inc.
Url:
DOI: 10.1002/gcc.22009
Affiliations:
- Allemagne, Danemark, France, Pays-Bas, Royaume-Uni
- Angleterre, Auvergne-Rhône-Alpes, Basse-Saxe, Berlin, District de Münster, Grand Londres, Rhénanie-du-Nord-Westphalie, Rhône-Alpes
- Berlin, Göttingen, Londres, Lyon, Münster
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- to stream Istex, to step Checkpoint: 000165
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- to stream Main, to step Curation: 003B37
- to stream Main, to step Exploration: 003B37
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Links to Exploration step
ISTEX:3FBCB282B381187920EDAFB9160E19595D9AA358Le document en format XML
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Heidelberg</wicri:noRegion></affiliation></author><author><name sortKey="Fisher, Cyril" sort="Fisher, Cyril" uniqKey="Fisher C" first="Cyril" last="Fisher">Cyril Fisher</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Pathology, The Royal Marsden Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pathology, University of Heidelberg</wicri:regionArea><wicri:noRegion>University of Heidelberg</wicri:noRegion><wicri:noRegion>University of Heidelberg</wicri:noRegion></affiliation></author><author><name sortKey="Hallermann, Christian" sort="Hallermann, Christian" uniqKey="Hallermann C" first="Christian" last="Hallermann">Christian Hallermann</name><affiliation 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Kiel</wicri:noRegion><wicri:noRegion>University of Kiel</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pathology, University of Heidelberg</wicri:regionArea><wicri:noRegion>University of Heidelberg</wicri:noRegion><wicri:noRegion>University of Heidelberg</wicri:noRegion></affiliation></author><author><name sortKey="Blay, Jean Ves" sort="Blay, Jean Ves" uniqKey="Blay J" first="Jean-Yves" last="Blay">Jean-Yves Blay</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Department of Medicine, Centre Léon Bérard, University Claude Bernard Lyon I, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pathology, University of Heidelberg</wicri:regionArea><wicri:noRegion>University of Heidelberg</wicri:noRegion><wicri:noRegion>University of Heidelberg</wicri:noRegion></affiliation></author><author><name sortKey="Mechtersheimer, Gunhild" sort="Mechtersheimer, Gunhild" uniqKey="Mechtersheimer G" first="Gunhild" last="Mechtersheimer">Gunhild Mechtersheimer</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Clinic of Internal Medicine II, University of Kiel</wicri:regionArea><wicri:noRegion>University of Kiel</wicri:noRegion><wicri:noRegion>University of Kiel</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pathology, University of Heidelberg</wicri:regionArea><wicri:noRegion>University of Heidelberg</wicri:noRegion><wicri:noRegion>University of Heidelberg</wicri:noRegion></affiliation></author><author><name sortKey="Hohenberger, Peter" sort="Hohenberger, Peter" uniqKey="Hohenberger P" first="Peter" last="Hohenberger">Peter Hohenberger</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Surgery, Division of Surgical Oncology and Thoracic Surgery, University Medical Center Mannheim, University of Heidelberg</wicri:regionArea><wicri:noRegion>University of Heidelberg</wicri:noRegion><wicri:noRegion>University of Heidelberg</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pathology, University of Heidelberg</wicri:regionArea><wicri:noRegion>University of Heidelberg</wicri:noRegion><wicri:noRegion>University of Heidelberg</wicri:noRegion></affiliation></author><author><name sortKey="Strobel, Philipp" sort="Strobel, Philipp" uniqKey="Strobel P" first="Philipp" last="Ströbel">Philipp Ströbel</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pathology, University Medical Center Mannheim, University of Heidelberg</wicri:regionArea><wicri:noRegion>University of Heidelberg</wicri:noRegion><wicri:noRegion>University of Heidelberg</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pathology, University Medical Center Göttingen, University of Göttingen</wicri:regionArea><wicri:noRegion>University of Göttingen</wicri:noRegion><wicri:noRegion>University of Göttingen</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pathology, University of Heidelberg</wicri:regionArea><wicri:noRegion>University of Heidelberg</wicri:noRegion><wicri:noRegion>University of Heidelberg</wicri:noRegion></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pathology, University Medical Center Göttingen, Robert‐Koch‐Str. 40, 37075 Göttingen</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Göttingen</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Genes, Chromosomes and Cancer</title><title level="j" type="alt">GENES, CHROMOSOMES AND CANCER</title><idno type="ISSN">1045-2257</idno><idno type="eISSN">1098-2264</idno><imprint><biblScope unit="vol">52</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="93">93</biblScope><biblScope unit="page" to="98">98</biblScope><biblScope unit="page-count">6</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2013-01">2013-01</date></imprint><idno type="ISSN">1045-2257</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1045-2257</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Irradiation is a major causative factor among the small subgroup of sarcomas with a known etiology. The prognosis of radiation‐induced sarcomas (RIS) is significantly worse than that of their spontaneous counterparts. The most frequent histological subtypes include undifferentiated pleomorphic sarcomas, angiosarcomas, and leiomyosarcomas. A high frequency of MYC amplifications in radiation‐induced angiosarcomas, but not in primary angiosarcomas, has recently been described. To investigate whether MYC amplifications are also frequent in RIS other than angiosarcomas, we analyzed the MYC amplification status of 83 RIS and 192 sporadic sarcomas by fluorescence in situ hybridization. We found significantly higher numbers of MYC amplifications in RIS than in sporadic sarcomas (P < 0.0001), especially in angiosarcomas, undifferentiated pleomorphic sarcomas, and leiomyosarcomas. Angiosarcomas were special in that MYC amplifications were particularly frequent and always high level, while other RIS showed low‐level amplifications. We conclude that MYC amplifications are a frequent feature of RIS as a group and may contribute to the biology of these tumors. © 2012 Wiley Periodicals, Inc.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Danemark</li><li>France</li><li>Pays-Bas</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Auvergne-Rhône-Alpes</li><li>Basse-Saxe</li><li>Berlin</li><li>District de Münster</li><li>Grand Londres</li><li>Rhénanie-du-Nord-Westphalie</li><li>Rhône-Alpes</li></region><settlement><li>Berlin</li><li>Göttingen</li><li>Londres</li><li>Lyon</li><li>Münster</li></settlement></list><tree><country name="Allemagne"><noRegion><name sortKey="K Cker, Christoph" sort="K Cker, Christoph" uniqKey="K Cker C" first="Christoph" last="K Cker">Christoph K Cker</name></noRegion><name sortKey="Blay, Jean Ves" sort="Blay, Jean Ves" uniqKey="Blay J" first="Jean-Yves" last="Blay">Jean-Yves Blay</name><name sortKey="Fisher, Cyril" sort="Fisher, Cyril" uniqKey="Fisher C" first="Cyril" last="Fisher">Cyril Fisher</name><name sortKey="Hallermann, Christian" sort="Hallermann, Christian" uniqKey="Hallermann C" first="Christian" last="Hallermann">Christian Hallermann</name><name sortKey="Hallermann, Christian" sort="Hallermann, Christian" uniqKey="Hallermann C" first="Christian" last="Hallermann">Christian Hallermann</name><name sortKey="Hartmann, Jorg Thomas" sort="Hartmann, Jorg Thomas" uniqKey="Hartmann J" first="Jörg Thomas" last="Hartmann">Jörg Thomas Hartmann</name><name sortKey="Hartmann, Jorg Thomas" sort="Hartmann, Jorg Thomas" uniqKey="Hartmann J" first="Jörg Thomas" last="Hartmann">Jörg Thomas Hartmann</name><name sortKey="Hogendoorn, Pancras Cornelis Wilhelmus" sort="Hogendoorn, Pancras Cornelis Wilhelmus" uniqKey="Hogendoorn P" first="Pancras Cornelis Wilhelmus" last="Hogendoorn">Pancras Cornelis Wilhelmus Hogendoorn</name><name sortKey="Hohenberger, Peter" sort="Hohenberger, Peter" uniqKey="Hohenberger P" first="Peter" last="Hohenberger">Peter Hohenberger</name><name sortKey="Hohenberger, Peter" sort="Hohenberger, Peter" uniqKey="Hohenberger P" first="Peter" last="Hohenberger">Peter Hohenberger</name><name sortKey="K Cker, Christoph" sort="K Cker, Christoph" uniqKey="K Cker C" first="Christoph" last="K Cker">Christoph K Cker</name><name sortKey="Kuffer, Stefan" sort="Kuffer, Stefan" uniqKey="Kuffer S" first="Stefan" last="Küffer">Stefan Küffer</name><name sortKey="Kuffer, Stefan" sort="Kuffer, Stefan" uniqKey="Kuffer S" first="Stefan" last="Küffer">Stefan Küffer</name><name sortKey="Marx, Alexander" sort="Marx, Alexander" uniqKey="Marx A" first="Alexander" last="Marx">Alexander Marx</name><name sortKey="Marx, Alexander" sort="Marx, Alexander" uniqKey="Marx A" first="Alexander" last="Marx">Alexander Marx</name><name sortKey="Mechtersheimer, Gunhild" sort="Mechtersheimer, Gunhild" uniqKey="Mechtersheimer G" first="Gunhild" last="Mechtersheimer">Gunhild Mechtersheimer</name><name sortKey="Mechtersheimer, Gunhild" sort="Mechtersheimer, Gunhild" uniqKey="Mechtersheimer G" first="Gunhild" last="Mechtersheimer">Gunhild Mechtersheimer</name><name sortKey="Mossinger, Katharina" sort="Mossinger, Katharina" uniqKey="Mossinger K" first="Katharina" last="Mössinger">Katharina Mössinger</name><name sortKey="Mossinger, Katharina" sort="Mossinger, Katharina" uniqKey="Mossinger K" first="Katharina" last="Mössinger">Katharina Mössinger</name><name sortKey="Nielsen, Ole Steen" sort="Nielsen, Ole Steen" uniqKey="Nielsen O" first="Ole Steen" last="Nielsen">Ole Steen Nielsen</name><name sortKey="Sauer, Christian" sort="Sauer, Christian" uniqKey="Sauer C" first="Christian" last="Sauer">Christian Sauer</name><name sortKey="Sauer, Christian" sort="Sauer, Christian" uniqKey="Sauer C" first="Christian" last="Sauer">Christian Sauer</name><name sortKey="Schneider, Ulrike" sort="Schneider, Ulrike" uniqKey="Schneider U" first="Ulrike" last="Schneider">Ulrike Schneider</name><name sortKey="Schneider, Ulrike" sort="Schneider, Ulrike" uniqKey="Schneider U" first="Ulrike" last="Schneider">Ulrike Schneider</name><name sortKey="Strobel, Philipp" sort="Strobel, Philipp" uniqKey="Strobel P" first="Philipp" last="Ströbel">Philipp Ströbel</name><name sortKey="Strobel, Philipp" sort="Strobel, Philipp" uniqKey="Strobel P" first="Philipp" last="Ströbel">Philipp Ströbel</name><name sortKey="Strobel, Philipp" sort="Strobel, Philipp" uniqKey="Strobel P" first="Philipp" last="Ströbel">Philipp Ströbel</name><name sortKey="Strobel, Philipp" sort="Strobel, Philipp" uniqKey="Strobel P" first="Philipp" last="Ströbel">Philipp Ströbel</name><name sortKey="Svehla, Frederike" sort="Svehla, Frederike" uniqKey="Svehla F" first="Frederike" last="Svehla">Frederike Svehla</name><name sortKey="Svehla, Frederike" sort="Svehla, Frederike" uniqKey="Svehla F" first="Frederike" last="Svehla">Frederike Svehla</name></country><country name="Pays-Bas"><noRegion><name sortKey="Hogendoorn, Pancras Cornelis Wilhelmus" sort="Hogendoorn, Pancras Cornelis Wilhelmus" uniqKey="Hogendoorn P" first="Pancras Cornelis Wilhelmus" last="Hogendoorn">Pancras Cornelis Wilhelmus Hogendoorn</name></noRegion></country><country name="Danemark"><noRegion><name sortKey="Nielsen, Ole Steen" sort="Nielsen, Ole Steen" uniqKey="Nielsen O" first="Ole Steen" last="Nielsen">Ole Steen Nielsen</name></noRegion></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Fisher, Cyril" sort="Fisher, Cyril" uniqKey="Fisher C" first="Cyril" last="Fisher">Cyril Fisher</name></region></country><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Blay, Jean Ves" sort="Blay, Jean Ves" uniqKey="Blay J" first="Jean-Yves" last="Blay">Jean-Yves Blay</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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